Medicated chewing gum is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement exists between visually perceived movement and the vestibular systems sense of movement. Diphenhydramine HCl is anti-histaminic, anti-emetic drug used to treat the symptoms associated with motion sickness, nausea and vomiting, vertigo and insect bite. Taste masking of diphenhydramine HCl will be done by complexing with β-cyclodextrin. Medicated chewing gum formulations were prepared using health in gums as a gum base in different concentration using diphenhydramine HCl for the treatment of motion sickness by direct compression method. Pre-compression and post-compression characteristics were studied. In-vitro dissolution studies were carried out by using modified chewing gum dissolution apparatus. The selected formulation was subjected to stability studies and no significant variation was observed. Hence it could be concluded that medicated chewing gum containing diphenhydramine HCl can be successfully formulated for the treatment of motion sickness.
Loading....